Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.
Identifieur interne : 000520 ( Main/Exploration ); précédent : 000519; suivant : 000521Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.
Auteurs : Nathan Meade [États-Unis] ; Colleen Furey [États-Unis] ; Hua Li [États-Unis] ; Rita Verma [États-Unis] ; Qingqing Chai [États-Unis] ; Madeline G. Rollins [États-Unis] ; Stephen Digiuseppe [États-Unis] ; Mojgan H. Naghavi [États-Unis] ; Derek Walsh [États-Unis]Source :
- Cell [ 1097-4172 ] ; 2018.
Descripteurs français
- KwdFr :
- Appareil de Golgi (métabolisme), Cellules HEK293 (MeSH), Cinétique (MeSH), Compagnon de mTOR insensible à la rapamycine (métabolisme), Cytoplasme (métabolisme), Cytosol (composition chimique), Homéostasie (MeSH), Humains (MeSH), Immunité innée (MeSH), Interférons (métabolisme), Lignée cellulaire (MeSH), Phosphorylation (MeSH), Poxviridae (métabolisme), Protéine de régulation associée à mTOR (métabolisme), Protéines de transport (métabolisme), Protéines proto-oncogènes c-akt (métabolisme), Réticulum endoplasmique (métabolisme), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (MeSH).
- MESH :
- composition chimique : Cytosol.
- métabolisme : Appareil de Golgi, Compagnon de mTOR insensible à la rapamycine, Cytoplasme, Interférons, Poxviridae, Protéine de régulation associée à mTOR, Protéines de transport, Protéines proto-oncogènes c-akt, Réticulum endoplasmique, Sérine-thréonine kinases TOR.
- Cellules HEK293, Cinétique, Homéostasie, Humains, Immunité innée, Lignée cellulaire, Phosphorylation, Transduction du signal.
English descriptors
- KwdEn :
- Carrier Proteins (metabolism), Cell Line (MeSH), Cytoplasm (metabolism), Cytosol (chemistry), Endoplasmic Reticulum (metabolism), Golgi Apparatus (metabolism), HEK293 Cells (MeSH), Homeostasis (MeSH), Humans (MeSH), Immunity, Innate (MeSH), Interferons (metabolism), Kinetics (MeSH), Phosphorylation (MeSH), Poxviridae (metabolism), Proto-Oncogene Proteins c-akt (metabolism), Rapamycin-Insensitive Companion of mTOR Protein (metabolism), Regulatory-Associated Protein of mTOR (metabolism), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (metabolism).
- MESH :
- chemical , metabolism : Carrier Proteins, Interferons, Proto-Oncogene Proteins c-akt, Rapamycin-Insensitive Companion of mTOR Protein, Regulatory-Associated Protein of mTOR, TOR Serine-Threonine Kinases.
- chemistry : Cytosol.
- metabolism : Cytoplasm, Endoplasmic Reticulum, Golgi Apparatus, Poxviridae.
- Cell Line, HEK293 Cells, Homeostasis, Humans, Immunity, Innate, Kinetics, Phosphorylation, Signal Transduction.
Abstract
Viruses employ elaborate strategies to coopt the cellular processes they require to replicate while simultaneously thwarting host antiviral responses. In many instances, how this is accomplished remains poorly understood. Here, we identify a protein, F17 encoded by cytoplasmically replicating poxviruses, that binds and sequesters Raptor and Rictor, regulators of mammalian target of rapamycin complexes mTORC1 and mTORC2, respectively. This disrupts mTORC1-mTORC2 crosstalk that coordinates host responses to poxvirus infection. During infection with poxvirus lacking F17, cGAS accumulates together with endoplasmic reticulum vesicles around the Golgi, where activated STING puncta form, leading to interferon-stimulated gene expression. By contrast, poxvirus expressing F17 dysregulates mTOR, which localizes to the Golgi and blocks these antiviral responses in part through mTOR-dependent cGAS degradation. Ancestral conservation of Raptor/Rictor across eukaryotes, along with expression of F17 across poxviruses, suggests that mTOR dysregulation forms a conserved poxvirus strategy to counter cytosolic sensing while maintaining the metabolic benefits of mTOR activity.
DOI: 10.1016/j.cell.2018.06.053
PubMed: 30078703
PubMed Central: PMC6172959
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.</title><author><name sortKey="Meade, Nathan" sort="Meade, Nathan" uniqKey="Meade N" first="Nathan" last="Meade">Nathan Meade</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Furey, Colleen" sort="Furey, Colleen" uniqKey="Furey C" first="Colleen" last="Furey">Colleen Furey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Li, Hua" sort="Li, Hua" uniqKey="Li H" first="Hua" last="Li">Hua Li</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Verma, Rita" sort="Verma, Rita" uniqKey="Verma R" first="Rita" last="Verma">Rita Verma</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Chai, Qingqing" sort="Chai, Qingqing" uniqKey="Chai Q" first="Qingqing" last="Chai">Qingqing Chai</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Rollins, Madeline G" sort="Rollins, Madeline G" uniqKey="Rollins M" first="Madeline G" last="Rollins">Madeline G. Rollins</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Digiuseppe, Stephen" sort="Digiuseppe, Stephen" uniqKey="Digiuseppe S" first="Stephen" last="Digiuseppe">Stephen Digiuseppe</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Naghavi, Mojgan H" sort="Naghavi, Mojgan H" uniqKey="Naghavi M" first="Mojgan H" last="Naghavi">Mojgan H. Naghavi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Walsh, Derek" sort="Walsh, Derek" uniqKey="Walsh D" first="Derek" last="Walsh">Derek Walsh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: derek.walsh@northwestern.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30078703</idno><idno type="pmid">30078703</idno><idno type="doi">10.1016/j.cell.2018.06.053</idno><idno type="pmc">PMC6172959</idno><idno type="wicri:Area/Main/Corpus">000488</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000488</idno><idno type="wicri:Area/Main/Curation">000488</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000488</idno><idno type="wicri:Area/Main/Exploration">000488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.</title><author><name sortKey="Meade, Nathan" sort="Meade, Nathan" uniqKey="Meade N" first="Nathan" last="Meade">Nathan Meade</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Furey, Colleen" sort="Furey, Colleen" uniqKey="Furey C" first="Colleen" last="Furey">Colleen Furey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Li, Hua" sort="Li, Hua" uniqKey="Li H" first="Hua" last="Li">Hua Li</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Verma, Rita" sort="Verma, Rita" uniqKey="Verma R" first="Rita" last="Verma">Rita Verma</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Chai, Qingqing" sort="Chai, Qingqing" uniqKey="Chai Q" first="Qingqing" last="Chai">Qingqing Chai</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Rollins, Madeline G" sort="Rollins, Madeline G" uniqKey="Rollins M" first="Madeline G" last="Rollins">Madeline G. Rollins</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Digiuseppe, Stephen" sort="Digiuseppe, Stephen" uniqKey="Digiuseppe S" first="Stephen" last="Digiuseppe">Stephen Digiuseppe</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Naghavi, Mojgan H" sort="Naghavi, Mojgan H" uniqKey="Naghavi M" first="Mojgan H" last="Naghavi">Mojgan H. Naghavi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Walsh, Derek" sort="Walsh, Derek" uniqKey="Walsh D" first="Derek" last="Walsh">Derek Walsh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: derek.walsh@northwestern.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">Cell</title><idno type="eISSN">1097-4172</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carrier Proteins (metabolism)</term><term>Cell Line (MeSH)</term><term>Cytoplasm (metabolism)</term><term>Cytosol (chemistry)</term><term>Endoplasmic Reticulum (metabolism)</term><term>Golgi Apparatus (metabolism)</term><term>HEK293 Cells (MeSH)</term><term>Homeostasis (MeSH)</term><term>Humans (MeSH)</term><term>Immunity, Innate (MeSH)</term><term>Interferons (metabolism)</term><term>Kinetics (MeSH)</term><term>Phosphorylation (MeSH)</term><term>Poxviridae (metabolism)</term><term>Proto-Oncogene Proteins c-akt (metabolism)</term><term>Rapamycin-Insensitive Companion of mTOR Protein (metabolism)</term><term>Regulatory-Associated Protein of mTOR (metabolism)</term><term>Signal Transduction (MeSH)</term><term>TOR Serine-Threonine Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Appareil de Golgi (métabolisme)</term><term>Cellules HEK293 (MeSH)</term><term>Cinétique (MeSH)</term><term>Compagnon de mTOR insensible à la rapamycine (métabolisme)</term><term>Cytoplasme (métabolisme)</term><term>Cytosol (composition chimique)</term><term>Homéostasie (MeSH)</term><term>Humains (MeSH)</term><term>Immunité innée (MeSH)</term><term>Interférons (métabolisme)</term><term>Lignée cellulaire (MeSH)</term><term>Phosphorylation (MeSH)</term><term>Poxviridae (métabolisme)</term><term>Protéine de régulation associée à mTOR (métabolisme)</term><term>Protéines de transport (métabolisme)</term><term>Protéines proto-oncogènes c-akt (métabolisme)</term><term>Réticulum endoplasmique (métabolisme)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carrier Proteins</term><term>Interferons</term><term>Proto-Oncogene Proteins c-akt</term><term>Rapamycin-Insensitive Companion of mTOR Protein</term><term>Regulatory-Associated Protein of mTOR</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cytosol</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Cytosol</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cytoplasm</term><term>Endoplasmic Reticulum</term><term>Golgi Apparatus</term><term>Poxviridae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Appareil de Golgi</term><term>Compagnon de mTOR insensible à la rapamycine</term><term>Cytoplasme</term><term>Interférons</term><term>Poxviridae</term><term>Protéine de régulation associée à mTOR</term><term>Protéines de transport</term><term>Protéines proto-oncogènes c-akt</term><term>Réticulum endoplasmique</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>HEK293 Cells</term><term>Homeostasis</term><term>Humans</term><term>Immunity, Innate</term><term>Kinetics</term><term>Phosphorylation</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HEK293</term><term>Cinétique</term><term>Homéostasie</term><term>Humains</term><term>Immunité innée</term><term>Lignée cellulaire</term><term>Phosphorylation</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viruses employ elaborate strategies to coopt the cellular processes they require to replicate while simultaneously thwarting host antiviral responses. In many instances, how this is accomplished remains poorly understood. Here, we identify a protein, F17 encoded by cytoplasmically replicating poxviruses, that binds and sequesters Raptor and Rictor, regulators of mammalian target of rapamycin complexes mTORC1 and mTORC2, respectively. This disrupts mTORC1-mTORC2 crosstalk that coordinates host responses to poxvirus infection. During infection with poxvirus lacking F17, cGAS accumulates together with endoplasmic reticulum vesicles around the Golgi, where activated STING puncta form, leading to interferon-stimulated gene expression. By contrast, poxvirus expressing F17 dysregulates mTOR, which localizes to the Golgi and blocks these antiviral responses in part through mTOR-dependent cGAS degradation. Ancestral conservation of Raptor/Rictor across eukaryotes, along with expression of F17 across poxviruses, suggests that mTOR dysregulation forms a conserved poxvirus strategy to counter cytosolic sensing while maintaining the metabolic benefits of mTOR activity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30078703</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-4172</ISSN><JournalIssue CitedMedium="Internet"><Volume>174</Volume><Issue>5</Issue><PubDate><Year>2018</Year><Month>08</Month><Day>23</Day></PubDate></JournalIssue><Title>Cell</Title><ISOAbbreviation>Cell</ISOAbbreviation></Journal><ArticleTitle>Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.</ArticleTitle><Pagination><MedlinePgn>1143-1157.e17</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0092-8674(18)30856-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cell.2018.06.053</ELocationID><Abstract><AbstractText>Viruses employ elaborate strategies to coopt the cellular processes they require to replicate while simultaneously thwarting host antiviral responses. In many instances, how this is accomplished remains poorly understood. Here, we identify a protein, F17 encoded by cytoplasmically replicating poxviruses, that binds and sequesters Raptor and Rictor, regulators of mammalian target of rapamycin complexes mTORC1 and mTORC2, respectively. This disrupts mTORC1-mTORC2 crosstalk that coordinates host responses to poxvirus infection. During infection with poxvirus lacking F17, cGAS accumulates together with endoplasmic reticulum vesicles around the Golgi, where activated STING puncta form, leading to interferon-stimulated gene expression. By contrast, poxvirus expressing F17 dysregulates mTOR, which localizes to the Golgi and blocks these antiviral responses in part through mTOR-dependent cGAS degradation. Ancestral conservation of Raptor/Rictor across eukaryotes, along with expression of F17 across poxviruses, suggests that mTOR dysregulation forms a conserved poxvirus strategy to counter cytosolic sensing while maintaining the metabolic benefits of mTOR activity.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Meade</LastName><ForeName>Nathan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Furey</LastName><ForeName>Colleen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verma</LastName><ForeName>Rita</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chai</LastName><ForeName>Qingqing</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rollins</LastName><ForeName>Madeline G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DiGiuseppe</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naghavi</LastName><ForeName>Mojgan H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walsh</LastName><ForeName>Derek</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: derek.walsh@northwestern.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R21 AI105330</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 GM008061</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 GM101975</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AI117943</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI127456</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 AI007476</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>08</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell</MedlineTA><NlmUniqueID>0413066</NlmUniqueID><ISSNLinking>0092-8674</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C492571">RICTOR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C463659">RPTOR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000076226">Rapamycin-Insensitive Companion of mTOR Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000076223">Regulatory-Associated Protein of mTOR</NameOfSubstance></Chemical><Chemical><RegistryNumber>9008-11-1</RegistryNumber><NameOfSubstance UI="D007372">Interferons</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="C494918">AKT1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003593" MajorTopicYN="N">Cytoplasm</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003600" MajorTopicYN="N">Cytosol</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004721" MajorTopicYN="N">Endoplasmic Reticulum</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006056" MajorTopicYN="N">Golgi Apparatus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007372" MajorTopicYN="N">Interferons</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011212" MajorTopicYN="N">Poxviridae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000076226" MajorTopicYN="N">Rapamycin-Insensitive Companion of mTOR Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000076223" MajorTopicYN="N">Regulatory-Associated Protein of mTOR</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">STING</Keyword><Keyword MajorTopicYN="Y">cGAS</Keyword><Keyword MajorTopicYN="Y">innate immunity</Keyword><Keyword MajorTopicYN="Y">interferon</Keyword><Keyword MajorTopicYN="Y">mTOR</Keyword><Keyword MajorTopicYN="Y">poxvirus</Keyword><Keyword MajorTopicYN="Y">protein synthesis</Keyword><Keyword MajorTopicYN="Y">sensor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>12</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>04</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>06</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>5</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30078703</ArticleId><ArticleId IdType="pii">S0092-8674(18)30856-0</ArticleId><ArticleId IdType="doi">10.1016/j.cell.2018.06.053</ArticleId><ArticleId IdType="pmc">PMC6172959</ArticleId><ArticleId IdType="mid">NIHMS1506865</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Mol Cell. 2010 Jun 11;38(5):768-74</Citation><ArticleIdList><ArticleId IdType="pubmed">20542007</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2013;9(10):e1003649</Citation><ArticleIdList><ArticleId IdType="pubmed">24098118</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2018 Feb 28;:null</Citation><ArticleIdList><ArticleId IdType="pubmed">29491158</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1991 Nov;65(11):6101-10</Citation><ArticleIdList><ArticleId IdType="pubmed">1920628</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6932-E6941</Citation><ArticleIdList><ArticleId IdType="pubmed">28760985</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2017 Nov 2;171(4):809-823.e13</Citation><ArticleIdList><ArticleId IdType="pubmed">29056340</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1773-81</Citation><ArticleIdList><ArticleId IdType="pubmed">25831530</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2014 Sep 1;193(5):2394-404</Citation><ArticleIdList><ArticleId IdType="pubmed">25070851</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2017 Apr 6;169(2):361-371</Citation><ArticleIdList><ArticleId IdType="pubmed">28388417</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2009 Nov 10;394(1):73-81</Citation><ArticleIdList><ArticleId IdType="pubmed">19744687</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2011 Jun 10;332(6035):1322-6</Citation><ArticleIdList><ArticleId IdType="pubmed">21659605</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Jan;78(1):399-412</Citation><ArticleIdList><ArticleId IdType="pubmed">14671121</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2013 Dec 12;39(6):1132-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24269171</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2013 Feb 15;339(6121):786-91</Citation><ArticleIdList><ArticleId IdType="pubmed">23258413</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2005 Feb 18;307(5712):1098-101</Citation><ArticleIdList><ArticleId IdType="pubmed">15718470</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2013 Jul 26;341(6144):1236566</Citation><ArticleIdList><ArticleId IdType="pubmed">23888043</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Virol. 2016 Sep 29;3(1):283-307</Citation><ArticleIdList><ArticleId IdType="pubmed">27501262</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2016 Sep 20;17(10):1142-9</Citation><ArticleIdList><ArticleId IdType="pubmed">27648547</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2017 Feb 13;8:14392</Citation><ArticleIdList><ArticleId IdType="pubmed">28194029</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2009 May 26;106(21):8653-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19433799</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 1990 Jun 25;18(12):3587-96</Citation><ArticleIdList><ArticleId IdType="pubmed">2194165</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2008 Oct 17;29(4):538-50</Citation><ArticleIdList><ArticleId IdType="pubmed">18818105</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Rep. 2013 May 30;3(5):1355-61</Citation><ArticleIdList><ArticleId IdType="pubmed">23707065</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2013 Nov 25;203(4):563-74</Citation><ArticleIdList><ArticleId IdType="pubmed">24385483</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomolecules. 2017 Nov 01;7(4):null</Citation><ArticleIdList><ArticleId IdType="pubmed">29104218</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comput Chem. 2004 Oct;25(13):1605-12</Citation><ArticleIdList><ArticleId IdType="pubmed">15264254</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2013 Jul 25;51(2):226-35</Citation><ArticleIdList><ArticleId IdType="pubmed">23747010</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2002 Jul 26;110(2):177-89</Citation><ArticleIdList><ArticleId IdType="pubmed">12150926</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2013 Aug 23;341(6148):903-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23929945</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2017 Aug 30;13(8):e1006602</Citation><ArticleIdList><ArticleId IdType="pubmed">28854224</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2010 Apr 16;141(2):290-303</Citation><ArticleIdList><ArticleId IdType="pubmed">20381137</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2008 Apr;28(8):2648-58</Citation><ArticleIdList><ArticleId IdType="pubmed">18250159</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2006 Feb 15;20(4):461-72</Citation><ArticleIdList><ArticleId IdType="pubmed">16481474</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620</Citation><ArticleIdList><ArticleId IdType="pubmed">28533362</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2016 Jan 1;351(6268):48-52</Citation><ArticleIdList><ArticleId IdType="pubmed">26678875</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2007 May 17;1(3):187-97</Citation><ArticleIdList><ArticleId IdType="pubmed">18005698</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2009 Mar 26;458(7237):514-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19158675</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2015 May;479-480:619-26</Citation><ArticleIdList><ArticleId IdType="pubmed">25728299</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Dec 9;280(49):40406-16</Citation><ArticleIdList><ArticleId IdType="pubmed">16221682</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10820-5</Citation><ArticleIdList><ArticleId IdType="pubmed">18669659</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Immunol. 2017 Oct;38(10):733-743</Citation><ArticleIdList><ArticleId IdType="pubmed">28416447</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2008 Oct 2;455(7213):674-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18724357</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2015 Jun 10;17(6):820-8</Citation><ArticleIdList><ArticleId IdType="pubmed">26048137</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3008-17</Citation><ArticleIdList><ArticleId IdType="pubmed">23027953</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Methods. 2012 Jun 28;9(7):676-82</Citation><ArticleIdList><ArticleId IdType="pubmed">22743772</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Jul;84(13):6846-60</Citation><ArticleIdList><ArticleId IdType="pubmed">20392848</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2010 Dec 1;24(23):2627-39</Citation><ArticleIdList><ArticleId IdType="pubmed">21123650</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2017 Jun 29;546(7660):651-655</Citation><ArticleIdList><ArticleId IdType="pubmed">28636603</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2009 Apr;83(8):3988-92</Citation><ArticleIdList><ArticleId IdType="pubmed">19211763</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2016 Apr;17(4):369-78</Citation><ArticleIdList><ArticleId IdType="pubmed">26829768</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Rep. 2015 Oct 13;13(2):440-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26440888</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2003 Apr;11(4):895-904</Citation><ArticleIdList><ArticleId IdType="pubmed">12718876</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2008 Jan;1784(1):228-37</Citation><ArticleIdList><ArticleId IdType="pubmed">17905673</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Virus Res. 2018;100:355-378</Citation><ArticleIdList><ArticleId IdType="pubmed">29551142</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2014 Apr 17;10(4):e1003989</Citation><ArticleIdList><ArticleId IdType="pubmed">24743339</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Protoc. 2012 Jul 19;7(8):1511-22</Citation><ArticleIdList><ArticleId IdType="pubmed">22814390</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Rep. 2017 Sep 19;20(12):2944-2954</Citation><ArticleIdList><ArticleId IdType="pubmed">28930687</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2012 Aug 17;150(4):831-41</Citation><ArticleIdList><ArticleId IdType="pubmed">22901812</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2011 Jun 10;332(6035):1317-22</Citation><ArticleIdList><ArticleId IdType="pubmed">21659604</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2009 Jul;83(13):6883-99</Citation><ArticleIdList><ArticleId IdType="pubmed">19386722</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2013 May 23;153(5):1094-107</Citation><ArticleIdList><ArticleId IdType="pubmed">23647843</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2013 Jun 20;498(7454):380-4</Citation><ArticleIdList><ArticleId IdType="pubmed">23722158</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2004 Mar 15;18(6):660-72</Citation><ArticleIdList><ArticleId IdType="pubmed">15075293</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Host Microbe. 2011 May 19;9(5):363-75</Citation><ArticleIdList><ArticleId IdType="pubmed">21575908</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2002 Jul 26;110(2):163-75</Citation><ArticleIdList><ArticleId IdType="pubmed">12150925</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2003 May 13;13(10):797-806</Citation><ArticleIdList><ArticleId IdType="pubmed">12747827</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2008 Mar 15;372(2):372-83</Citation><ArticleIdList><ArticleId IdType="pubmed">18054061</ArticleId></ArticleIdList></Reference><Reference><Citation>Elife. 2018 Feb 09;7:null</Citation><ArticleIdList><ArticleId IdType="pubmed">29424687</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Rep. 2013 Aug 15;4(3):464-76</Citation><ArticleIdList><ArticleId IdType="pubmed">23891003</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2004 Jul 27;14(14):1296-302</Citation><ArticleIdList><ArticleId IdType="pubmed">15268862</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2007 Dec 15;23(24):3403-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17921170</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2016 Apr 15;352(6283):359-62</Citation><ArticleIdList><ArticleId IdType="pubmed">27013426</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Meade, Nathan" sort="Meade, Nathan" uniqKey="Meade N" first="Nathan" last="Meade">Nathan Meade</name></region><name sortKey="Chai, Qingqing" sort="Chai, Qingqing" uniqKey="Chai Q" first="Qingqing" last="Chai">Qingqing Chai</name><name sortKey="Digiuseppe, Stephen" sort="Digiuseppe, Stephen" uniqKey="Digiuseppe S" first="Stephen" last="Digiuseppe">Stephen Digiuseppe</name><name sortKey="Furey, Colleen" sort="Furey, Colleen" uniqKey="Furey C" first="Colleen" last="Furey">Colleen Furey</name><name sortKey="Li, Hua" sort="Li, Hua" uniqKey="Li H" first="Hua" last="Li">Hua Li</name><name sortKey="Naghavi, Mojgan H" sort="Naghavi, Mojgan H" uniqKey="Naghavi M" first="Mojgan H" last="Naghavi">Mojgan H. Naghavi</name><name sortKey="Rollins, Madeline G" sort="Rollins, Madeline G" uniqKey="Rollins M" first="Madeline G" last="Rollins">Madeline G. Rollins</name><name sortKey="Verma, Rita" sort="Verma, Rita" uniqKey="Verma R" first="Rita" last="Verma">Rita Verma</name><name sortKey="Walsh, Derek" sort="Walsh, Derek" uniqKey="Walsh D" first="Derek" last="Walsh">Derek Walsh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000520 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000520 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:30078703
|texte= Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30078703" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |